APCgenencbi

The APC gene encodes a large protein of roughly 300 kDa that is hypothesized to regulate cell adhesion, cell migration, or perhaps even apoptosis in the colonic ...

由 HL Wong 著作 · 2010 · 被引用 47 次 — Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. ... Follow NCBI. Connect with NLM. National ...

由 W Hankey 著作 · 2018 · 被引用 172 次 — Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene. ... Follow NCBI. Connect with NLM. National Library of Medicine

Genes, APC. Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial ...

2024年4月16日 — This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid ...

APC APC regulator of WNT signaling pathway [ Homo sapiens (human) ]. Gene ID: 324, updated on 21-May-2024. Download Datasets.

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell ...

由 T Yen 著作 · 2022 · 被引用 214 次 — Genetic counseling. APC-associated polyposis conditions are inherited in an autosomal dominant manner. Approximately 75%-80% of individuals with an APC- ...

2024年6月6日 — Adenomatous polyposis coli (APC) mutations found in human colorectal cancers dominantly inhibit cytokinesis by preventing mitotic spindle ...

由 S Majumder 著作 · 2018 · 被引用 9 次 — In this study, we identified a novel germline mutation in the APC gene in members of an FAP-affected (Familial adenomatous polyposis) family.