APCgenencbi

由 T Senda 著作 · 2005 · 被引用 83 次 — The adenomatous polyposis coli (Apc) gene is mutated in familial adenomatous polyposis and in sporadic colorectal tumors. The Apc gene product (APC), ...

由 K Aoki 著作 · 2007 · 被引用 629 次 — The adenomatous polyposis coli (APC) gene is a key tumor suppressor gene. Mutations in the gene have been found not only in most colon ...

5 天前 — This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes ...

APC APC regulator of WNT signaling pathway [ Homo sapiens (human) ]. Gene ID: 324, updated on 12-Dec-2023. Download Datasets.

2023年12月12日 — APC protein is associated with microtubules and is colocalized with kinesin heavy chain (KHC)and beta-catenin in immortalized YAMC cells.

由 T Yen 著作 · 2022 · 被引用 201 次 — APC-associated polyposis conditions are inherited in an autosomal dominant manner. Approximately 75%-80% of individuals with an APC-associated polyposis ...

2023年11月23日 — This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid ...

由 W Hankey 著作 · 2018 · 被引用 146 次 — Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene. ... Follow NCBI. Connect with NLM. National Library of Medicine

The APC gene encodes a large protein of roughly 300 kDa that is hypothesized to regulate cell adhesion, cell migration, or perhaps even apoptosis in the colonic ...

由 RB van der Luijt 著作 · 2000 · 被引用 4 次 — APC gene mutations cause the development of multiple adenomatous polyps in the colorectum, which strongly predisposes gene carriers to colorectal cancer.